**Brain can permanently changed due to prolong stress or drug use** - dopamine signalling regulated by the 5-HT2AR could play a key role in resolving acute distress or confusion, _and_ _yet_ a developmental dysregulation of these systems by stress or drugs in genetically susceptible individuals could eventually lead to psychosis and require antipsychotic intervention. Consistent with this view, some recurrent psychoses could [reflect](https://aeon.co/essays/delusions-take-root-in-minds-searching-to-explain-difficult-experiences) a repeated, yet dysfunctional, attempt to solve a social problem (eg, via delusional beliefs), which generally makes the problem only worse. [[What a spiritual high shares with a mental breakdown Aeon Essays]] #schizophrenia