[Malaria (who.int)](https://www.who.int/news-room/fact-sheets/detail/malaria) Malaria is caused by the Plasmodium parasite. - Plasmodium falciparum is the most dangerous and can cause severe and life-threatening malaria. It is responsible for the majority of malaria-related deaths, especially in sub-Saharan Africa. Malaria can lead to severe anemia, organ failure, cerebral malaria (affecting the brain), and other complications. Malaria-related deaths are more common in young children and pregnant women. - WHO approved RTS,S- the world's first malaria vaccine, marks a milestone in malaria research though the vaccine provides partial protection ([Zavala, 2022](https://www.frontiersin.org/articles/10.3389/fmicb.2023.1191773/full#B16)) Preventions 1. Vector control 2. Research 1. Vaccines 2. Disrupt parasites reproducing in the body - liver-stage 3. Manipulate the genetic of malaria mosquitoes 1. Genomics Dengue is caused by dengue virus. Africa - highest malaria burden --- [Frontiers | Editorial: Frontiers in malaria research](https://www.frontiersin.org/articles/10.3389/fmicb.2023.1191773/full) Cytoadherence is a property exhibited by certain Plasmodium parasites, the causative agents of malaria, whereby infected red blood cells adhere to the walls of blood vessels Rosetting is a phenomenon observed in some cases of Plasmodium falciparum malaria, where infected red blood cells adhere to uninfected red blood cells, forming clusters or rosettes. - Understanding how infected blood cells and interaction with host cells, can help develop strategies to prevent severe malaria --- https://www.nature.com/articles/s41467-023-38774-1#Sec9 They modified the P. falciparum genes, and it became more resistant to the drugs. They want to find out what causes the parasite to resist drugs. If they know the mechanism of drug resistance, then they can invent ways to counter that.