- Non-Adherence with medication - Persistent substance use - Carers' criticism (Or high expressed emotions) - Pooer Premorbid adjustment Source [[Article - The Nature of Relapse in Schizophrenia]] "Multiple factors contribute to increasing the risk of relapse. In a systematic review and meta-analysis of longitudinal studies it was found that non-adherence with medication, persistent substance use, carers' criticism and poorer premorbid adjustment significantly increased the risk for relapse in first-episode psychosis [5]."